Quinolone Use During Pregnancy: Is It Safe?
the MPR take:
Quinolones and fluoroquinolones are effective broad-spectrum antibiotics that are used to treat numerous infections; however, concerns about possible teratogenic effects seen in animal studies have limited their use during pregnancy. In a study published in the journal Obstetrical and Gynecological Survey, researchers aimed to review available data to see whether the use of these antibiotics during pregnancy should be re-evaluated. After reviewing thousands of cases, the researchers found that harmful effects were typically seen in animals when the antibiotic was given at higher than normal doses. In humans, no association was found between fluorquinolone use and an increased risk of major malformations or adverse pregnancy outcomes; ciprofloxacin was the most studied fluoroquinolone. Given that the majority of studies did not show harmful effects in humans, it may be advisable to consider the use of fluoroquinolones during pregnancy in cases of resistant strains or allergy, but only after the patient has been apprised of the possible risks. The authors caution that this study does have multiple limitations and that routine use of fluoroquinolones during pregnancy is still not recommended.
Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy.