Oxybutynin Deemed Effective for Hyperhidrosis
Martine Schollhammer, MD, from University Hospital in Brest, France, and colleagues examined the effectiveness and tolerance of low-dose oxybutynin for hyperhidrosis in a randomized placebo-controlled trial. Participants included 62 patients with localized or generalized hyperhidrosis (83% generalized). Oxybutynin was started at 2.5mg per day and increased to 7.5mg per day.
The researchers found that for improving the Hyperhidrosis Disease Severity Scale (HDSS), oxybutynin was superior to placebo, with improvement of at least one point on the HDSS for 60% of oxybutynin-treated patients vs. 27% of placebo-treated patients. The mean improvement in quality of life, as measured by the Dermatology Life Quality Index, was significantly better for oxybutynin vs. placebo treatment (6.9 vs. 2.3). Dry mouth was the most frequent side effect, which was seen in 43 and 11% of those in the oxybutynin and placebo arms, respectively.
"Treatment with low-dose oxybutynin is effective in reducing symptoms of hyperhidrosis in generalized or localized forms," the authors write.
One author disclosed financial ties to Pfizer.