Nitric Oxide Nanoparticles Target Inflammation in Acne
(HealthDay News) — By slowing the release of nitric oxide using nanoparticles (NO-np), researchers were able to prevent Propionibacterium acnes-induced inflammation by clearing the organism as well as inhibiting the innate immune response. The study was published online July 14 in the Journal of Investigative Dermatology.
The study focused on a pathway, involving inflammasomes, responsible for activating the inflammatory process in acne. The researchers found that P. acnes was highly sensitive to all concentrations of NO-np tested. Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-8 and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes were found to be significantly suppressed by NO-np.
The researchers determined that silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of IL-1β secretion from monocytes. TNF-α and IL-6 secretion, and inhibition by NO-np were not found to be dependent on this pathway. Inhibition of caspase-1 and IL-1β gene expression was cited as the observed mechanism by which NO-np impacts IL-1β secretion.
"Our understanding of acne has changed dramatically in the last 15 to 20 years," study coauthor Adam Friedman, M.D., an associate professor of dermatology at George Washington University in Washington, D.C., said in a university news release. "Inflammation is really the driving force behind all types of acne. In this paper, we provide an effective way to kill the bacterium that serves as a stimulus for acne without using an antibiotic, and demonstrate the means by which nitric oxide inhibits newly recognized pathways central to the formation of a pimple, present in the skin even before you can see the acne," he explained.