Most Commonly Reported Adverse Drug Events in Children, Adolescents
the MPR take:
A new study has found that while children and adolescents have similar types of adverse drug reactions to certain types of medications, the frequency in which they occur vary by age. Case reports submitted to the FDA Adverse Event Reporting System (FAERS) from January 1, 2007–August 27, 2012 were evaluated for children 1–<12 years of age and adolescents 12–<18 years of age, with the most commonly reported suspected drugs ranked and corresponding adverse events with serious outcomes compared. Children had a greater percentage of reported adverse outcomes with CNS stimulants (lisdexamfetamine 69.8%) and analgesics (ibuprofen 72.3%), while tumor necrosis factor blockers (infliximab 78.2%), atypical antipsychotics (aripiprazole 52.7%), and oral contraceptives (levonorgestrel 99.2%) were more commonly reported in adolescents. The most dissimilar types of reactions between the age groups occurred with the drugs isotretinoin and aripiprazole. The authors emphasize that additional research is needed on particular drugs and adverse events by age.
Drugs associated with adverse events in children and adolescents. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 07/07/2014. Clinical Article. Lee WJ, et al. – The authors aimed to describe the suspected medications, types of reactions, and outcomes of adverse events (AEs) most commonly reported to the United States Food and Drug Administration (FDA) in children by age group.
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