Metabolic Syndrome Common in Young Women With Lupus

This article originally appeared here.
Metabolic Syndrome Common in Young Women With Lupus
Metabolic Syndrome Common in Young Women With Lupus

(HealthDay News) – Metabolic syndrome is common in young, premenopausal women with systemic lupus erythematosus (SLE), and chloroquine appears to protect against metabolic syndrome in these women, according to a study published online Aug. 26 in Arthritis Care & Research.

Luciana F. Muniz, MD, from Faculdade de Medicina da Universidade de Sao Paulo in Brazil, and colleagues evaluated the frequency of metabolic syndrome and disease- or therapy-related factors in 103 premenopausal SLE patients (<40 years) and 35 healthy, premenopausal, age-matched women.

The researchers found a higher frequency of metabolic syndrome in the SLE group (22.3% vs. 5.7%; P=0.03). Compared with those without metabolic syndrome, SLE patients with metabolic syndrome had higher SLE Disease Activity Index scores (P=0.006), more frequently had previous renal disease (73.9% vs. 51.2%; P=0.05) and current renal disease (34.8% vs. 10%; P=0.008), and had higher current prednisone dose (P=0.018) and cumulative prednisone dose (P=0.023). Chloroquine was less frequently used in metabolic syndrome-SLE patients (65.2% vs. 90%; P=0.008). In multivariate analysis, only current chloroquine use (prevalence ratio [PR], 0.29) and cumulative prednisone were associated with metabolic syndrome (PR, 1.02).

"Chloroquine has a protective effect on the prevalence of metabolic syndrome in these patients, and this benefit counteracts the deleterious effect of glucocorticoids in a dose-dependent manner," the authors conclude.

Full Text (subscription or payment may be required)