Melanoma's Sugar Dependence Blocked
the MPR take:
With approximately 40% of melanomas caused by BRAF gene mutations and dependent on glucose for cancer cell growth, researchers have discovered a way to control tumor growth with specific drug therapy. Tiffany Parmenter and colleagues at the Peter MacCallum Cancer Centre in Australia saw that by reducing the high use of glucose by the tumors, they were able to halt the growth of the tumors anywhere from a few weeks to a few years. The tumors became resistant to the drug effects after the growth restarted and the glucose supply was replenished. The team hopes to develop new treatments to kill the remaining cancer cells by blocking the genes in charge of use and regulation of glucose.
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