Longer QRS Duration Can Predict Cardiac Death, Heart Attack
(HealthDay News) — Longer QRS duration predicts cardiac death and nonfatal myocardial infarction (MI) in patients with coronary artery disease, according to a study published in the November 1 issue of The American Journal of Cardiology.
Roy Huurman, from Erasmus Medical Center in the Netherlands, and colleagues investigated the long-term prognostic value of QRS duration in 512 patients (308 men) with known or suspected coronary artery disease who underwent myocardial perfusion imaging (MPI).
The researchers found that over a mean follow-up of 8.6 years, 290 patients died (60%), with 27% of these deaths attributable to cardiac causes. Twenty-eight patients (6%) had nonfatal MI, and 127 patients (25%) underwent late coronary revascularization (>three months). The annualized cardiac death rates and cardiac death or nonfatal MI rates were lower in patients with QRS duration <120 ms compared with those with QRS duration of ≥120 ms (2.2% and 2.3%, respectively, vs. 4.1% and 4.4%, respectively). In multivariate models, QRS duration ≥120 ms was an independent predictor of both end points, in addition to clinical characteristics and MPI results.
"In conclusion, QRS duration ≥120 ms is an independent predictor of cardiac death and cardiac death or nonfatal MI, after adjustment for clinical characteristics and MPI results," write the authors.