Is Pumpkin Seed Effective for Lower Urinary Tract Symptoms in Men?
the MPR take:
Can supplementing with pumpkin seed improve lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH)? A new study published in the journal Urologia Internationalis reports on a clinical trial involving 1,431 men with BPH/LUTS who were randomly assigned to receive either pumpkin seed extract capsules (500mg twice daily), pumpkin seed (5g twice daily) or placebo. Reduction in International Prostate Symptom Score (IPSS), from baseline to 12 months, of ≥5 points was the primary efficacy endpoint of the study. Secondary endpoints included improvements in quality of life and nocturia. After 12 months of treatment, no difference in response rate was seen between the pumpkin seed extract group and the placebo group. The pumpkin seed group did show significant response versus the placebo group (58.5% vs. 47.3%, respectively). In men with BPH, treatment with pumpkin seed led to clinically relevant IPSS reductions compared to placebo, however, the authors note that more studies need to be conducted before pumpkin seed can be recommended as a treatment for moderate LUTS.
The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS).