HIV-Infected Men at Risk for Heart Disease
the MPR take:
HIV-infected men are more likely to have coronary artery plaque than HIV-uninfected men, independent of cardiovascular disease risk factors. In a study published in the Annals of Internal Medicine, participants in the Multicenter AIDS Cohort Study (MACS) were evaluated for presence and extent of coronary artery calcium (CAC) on noncontrast cardiac computed tomography (CT) and of any plaque; noncalcified, mixed, or calcified plaque; or stenosis on coronary CT angiography. Compared to uninfected men, HIV-infected men had a greater prevalence of CAC and any plaque, including noncalcified and mixed, after adjustment for age, race, CT scanning center, and cohort. Additional research is needed to determine if coronary artery plaque is less likely to harden over time in HIV-infected men or if they develop greater amounts of soft plaque.
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