High-Dose Isotretinoin Evaluated for Acne Treatment, Relapse

the MPR take:

Isotretinoin is indicated for the treatment of severe recalcitrant nodular acne unresponsive to conventional therapy (eg, systemic antibiotics) but the ideal dosing regimen is unknown. In a study published in JAMA Dermatology, 116 patients with acne resistant to other treatments received isotretinoin at a cumulative dose of <220mg/kg or ≥220mg/kg for 12 months. Patients receiving the higher dose had a lower rate of acne relapse compared to the lower dose group (26.9 vs. 47.4%, respectively) with retinoid dermatitis being the only adverse effect more common in the high-dose group. The authors note that higher doses of isotretinoin could be effective for both acne treatment and reducing relapse rates.

High-Dose Isotretinoin Effective for Acne Relapse?
High-Dose Isotretinoin Effective for Acne Relapse?

JAMA Dermatology: High-Dose Isotretinoin Treatment and the Rate of Retrial, Relapse, and Adverse Effects in Patients With Acne Vulgaris. Rachel C. Of these, 116 participated in the 12-month follow-up survey, for a response rate of 64.4%. Exposure Patients received isotretinoin, with dosing based on the providers' judgment.

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