Duration of High-Dose Atorvastatin Therapy Post-Acute Coronary Syndrome
the MPR take:
A review published in the Journal of Pharmacology Practice sought to find out what the appropriate duration of high-dose atorvastatin therapy should be after acute coronary syndrome (ACS). Four major studies evaluating 80mg/day of atorvastatin after an ACS were included in the investigation; follow-up time for these studies ranged from 16 weeks to an average of 4.9 years. High-dose atorvastatin treatment was associated with a reduction in coronary events; however, it was also connected to higher rates of drug discontinuation due to adverse reactions. The studies support the sustained benefit of high-dose atorvastatin for at least five years, leading the authors to recommend this duration as well.
Purpose: To determine the optimal duration of high-intensity atorvastatin therapy post-acute coronary syndrome (ACS). Summary: A literature review was conducted using the MEDLINE database (1966-October 2013) and employing the search terms “atorvastatin OR statins AND myocardial infarction OR acute coronary syndromes.”