Does Renal Function Affect Lactic Acidosis Rates in Metformin Users?
the MPR take:
Lactic acidosis has been linked to metformin use in patients with type 2 diabetes and reduced renal function, but a new study has some surprising results on this topic. A retrospective analysis of 77,601 patients, published in the journal Diabetes Care, found no significant difference in rates of lactic acidosis among patients being treated for type 2 diabetes with metformin with normal, mildly reduced, moderately reduced, and severely reduced renal function. Rates of lactic acidosis in this research were within the range of rates found in previous studies as well.
OBJECTIVE: To determine whether the use of metformin in type 2 diabetic patients with various kidney functions is associated with an increased risk of lactic acidosis (LA).RESEARCH DESIGN AND METHODS This study was a retrospective analysis of U.K. Inclusion criteria were 1) diagnosis of type 2 diabetes before 1 January 2007, 2) treatment with metformin, and 3) at least one assessment of renal function between 2007 and 2012.
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