Do Antidepressants Increase Chronic A-Fib Risk?

the MPR take:

Because serotonin stimulation of the 5HT4 receptor may be linked to an increased risk of atrial fibrillation (AF), it is important to assess the risk of AF in patients with long-term exposure to antidepressants. From the UK Clinical Practice Research Datalink (CPRD), a cohort of 116,125 new users of antidepressants was identified and 1,270 cases of chronic atrial fibrillation (cAF) were reported over a minimum time of 6 months of follow-up. Although the patients taking antidepressants were more likely to have cardiovascular diseases and chronic respiratory conditions compared to the matched controls, the risk of cAF was not increased with current or recent use of antidepressants. No association with cAF was observed among users of SSRIs, TCAs, and other types of antidepressants; no additional association was seen based on potency of antidepressants. Because effective pharmacotherapy with antidepressants in reducing the risk of depression recurrences may need to continue long-term, these findings suggest that antidepressants will not increase the risk of cAF with long-term use.

Serotonin stimulation of the 5HT4 receptor might be responsible for an increased risk of atrial fibrillation (AF).