Do Anti-Inflammatory Drugs Have Antidepressant Effects?

the MPR take:

Does anti-inflammatory treatment also have antidepressant effects? A meta-analysis in JAMA Psychiatry reviewed 14 randomized clinical trials investigating the antidepressant effects of anti-inflammatory treatment in 6,262 adults. Ten trials evaluated the use of nonsteroidal anti-inflammatory drugs (NSAIDs) (n=4258) and four investigated cytokine inhibitors (n=2004). The pooled effect estimate suggested that anti-inflammatory treatment reduced depressive symptoms vs. placebo in studies of patients with depression and depressive symptoms. Particularly with add-on treatment, celecoxib showed improved antidepressant effects on remission and response. No evidence was seen of an increased number of gastrointestinal or cardiovascular events after six weeks or infections after 12 weeks of anti-inflammatory treatment vs. placebo. The authors warn that because there is high heterogeneity and a high risk of bias in the studies, the results should be interpreted with caution; however, subgroups may benefit from anti-inflammatory treatment such as patients with elevated inflammatory markers or a somatic comorbidity.

Several studies have reported antidepressant effects of anti-inflammatory treatment; however, the results have been conflicting and detrimental adverse effects may contraindicate the use of anti-inflammatory agents.