Death Due to SIAD: What Happens After Discharge?

the MPR take:

Little is known about mortality after hospital discharge in patients with syndrome of inappropriate antidiuresis (SIAD), but a new study published in the Journal of Clinical Pathology aimed to compare mortality in SIAD and kidney injury (KI) patients post-discharge and to identify the underlying causes associated with these deaths. In a retrospective cohort analysis of 804 patients with severe hyponatremia over a three-year period, 202 SIAD patients and 248 KI patients were followed for five years to compare mortality rates post-hospitalization. Patients with KI had statistically significantly shorter mean survival time vs. those with SIAD (2.24 months vs. 31.0 months, respectively). 53.8% of hyponatremia patients died within the first year post-admission due to SIAD, while the rate for those with KI was 74.1%. 80.0% of SIAD patients died within five years after hospital admission, compared to 88.4% of KI patients. It is notable that for SIAD patients, malignancy and infection were the most common causes of mortality (25.4% and 23.8%, respectively). Although severe hyponatremia in SIAD has a high mortality rate post-hospital discharge, more research needs to be done to see if the use of V2-receptor antagonists to correct the hyponatremia may influence patient outcomes.

What's Causing High SIAD Mortality?
What's Causing High SIAD Mortality?

Introduction: The syndrome of inappropriate antidiuresis (SIAD) is the commonest cause of euvolaemic hyponatraemia in patients admitted to hospital. The mortality after discharge from hospital has not been previously studied in patients with SIAD. Aims: To compare mortality in patients with SIAD and those with kidney injury (KI).