Can Tamsulosin Improve Urinary Symptoms in Women with Dysfunctional Voiding, Recurrent UTI?
the MPR take:
Recurrent urinary tract infections (UTI) can occur in as many as 42% of patients with dysfunctional voiding. Because α1-AR appear to have a role in lower urinary tract function, the use of α1-AR antagonists may be effective for female patients with dysfunctional voiding. A prospective study conducted from 2008–2012 included 155 nulliparous women <40 years with a 3+ year history of recurrent UTI and at least three or more symptomatic episodes over a 12-month period, to assess the therapeutic effects of tamsulosin on this population. The patients were assigned to receive uroflowmetry biofeedback, 0.4 mg tamsulosin once daily, biofeedback plus tamsulosin, or no treatment. Patients in the biofeedback plus tamsulosin group experienced significant improvements in mean flow rate, flow time, and voiding volume compared to the other groups. The prevalence of UTI decreased significantly in the three therapeutic groups after treatment and remained stable during the one year follow-up; no changes were seen in the control group. The results suggest that tamsulosin associated with uroflowmetry biofeedback may be an effective treatment option for women with dysfunctional voiding and recurrent UTI.
To evaluate the therapeutic effects of tamsulosin on recurrent urinary tract infections in women with dysfunctional voiding.