Bupropion/Naltrexone Combo Evaluated in Obesity Study
the MPR take:
This study published in the International Journal of Obesity discusses the effectiveness of the combination of bupropion SR 360mg + naltrexone SR 32mg in the treatment of obesity. Study results indicate that compared to placebo, this combination was able to not only decrease hypothalmic reactivity when patients were exposed to food cue videos, but also increase activation in the parts of the brain that are involved with self-control, awareness, and memory. Bupropion is currently marketed for the treatment of depression and smoking cessation; naltrexone is used for treating alcoholism and opioid addiction. The findings of this study will be used to continue research on this combination and its potential benefits as a treatment for obesity.
We assessed changes in brain reactivity to food cues before and after NB32 treatment. Forty women (31.1±8.1 years; body mass index: 32.5±3.9) received 4 weeks of NB32 or placebo, and were instructed to maintain their dietary and exercise habits. Functional magnetic resonance imaging (fMRI) ...
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