Associations Between Chorioamnionitis and Cognitive Development at Age 2, Examined
HealthDay News — Chorioamnionitis does not appear to be associated with decreased Bayley II scores at age 2 years, according to a study published in the March issue of Obstetrics & Gynecology.
Emilie Vander Haar, MD, and Cynthia Gyamfi-Bannerman, MD, from the Columbia University Medical Center in New York City, conducted an observational cohort study of women and their offspring enrolled in a controlled trial of magnesium for cerebral palsy prevention in pregnancies at high-risk of early preterm delivery. The authors examined the correlation between chorioamnionitis and decreased Bayley scores at age 2 years.
The researchers found that 12% of the 1,574 patients involved in the study had chorioamnionitis and 87% had preterm premature rupture of the membranes. Delivery was at a mean gestational age of 29 3/7 weeks. For children born to mothers with or without chorioamnionitis, there were no significant differences in Mental Developmental Index score less than 70 (19.1 versus 17%; P = 0.45) or Psychomotor Developmental Index score less than 70 (15 versus 14%; P = 0.76). No difference was seen in the proportion of abnormal scores in either group after adjustment for confounders. Significantly decreased mental Developmental Index scores were seen for neonates diagnosed with sepsis.
"We could not demonstrate an association between clinical chorioamnionitis and poor neurocognitive function as measured by Bayley scores," the authors write.