ASMBS: Bariatric Surgery Helps Resolve Diabetic Nephropathy
(HealthDay News) – For patients with diabetes who undergo bariatric surgery there is a significant long-term improvement in diabetic nephropathy.
To examine whether bariatric surgery would have positive effects on end-organ complications in diabetes, Helen M. Heneghan, MD, from the Cleveland Clinic Bariatric and Metabolic Institute, and colleagues followed 52 patients for five years; the patients had diabetes and had undergone bariatric surgery. The presence of diabetic nephropathy before and after surgery was assessed using the urinary albumin-creatinine ratio.
The researchers found that diabetic nephropathy was present in 35% of patients preoperatively. At a mean follow-up of 66 months it had resolved in 55% of these patients. Of those with no evidence of diabetic nephropathy before surgery, only 25% subsequently developed albuminuria five years later. The five-year remission rate was 22% and the five-year improvement rate was 55% in this patient sample, with mean reductions of 32mg/dL and 1.2% in fasting glucose and glycated hemoglobin, respectively.
"When we started this study, we thought bariatric surgery may just halt the progression of diabetic nephropathy; instead, over half of the patients who had diabetic nephropathy prior to undergoing bariatric surgery experienced remission," Heneghan said in a statement. "This is a remarkable finding that warrants greater consideration of bariatric surgery in this patient population."