Analgesic Efficacy of Glucosamine + Chondroitin in Knee OA
the MPR take:
For patients with knee osteoarthritis (OA), supplementation with glucosamine sulfate (GS) and chondroitin sulfate (CS) capsules or sachet preparations with glucosamine hydrochloride (GH) and CS capsules may significantly decrease pain intensity. A new study in Clinical Rheumatology randomized 1,120 patients with radiographic knee OA to GS 500mg/CS 400mg three times daily capsules, once daily sachet of GH and CS capsules, or GH 500mg/CS 400mg three times daily over the course of 16 weeks. Significantly reduced pain was reported among all three groups and secondary outcomes (changes from baseline in patient reported pain and Lequesne’s index) also improved for all. Non-inferiority analysis found no differences among the groups, regardless of dose fractionation or formulation.
Abstract: We compared the analgesic efficacy and safety of glucosamine sulfate (GS) and chondroitin sulfate (CS) capsules or sachet preparations with glucosamine hydrochloride (GH) and CS capsules in knee osteoarthritis (OA) patients.