β-Amyloid Brain Deposits Linked to Arterial Stiffness
(HealthDay News) — Cerebral β-amyloid (Aβ) deposition increases with age in nondemented individuals, and this deposition is strongly associated with arterial stiffness, according to a study published online March 31 in JAMA Neurology.
Timothy M. Hughes, PhD, from Wake Forest University in Winston-Salem, NC, and colleagues used positron emission tomography (PET) using the Pittsburgh compound B twice two years apart in 81 nondemented individuals (≥83 years) to assess deposition of Aβ. A noninvasive and automated waveform analyzer was used close in time to the second PET scan to determine arterial stiffness.
The researchers found that the proportion of Aβ-positive individuals increased from 48% at baseline to 75% at follow-up. Among Aβ-positive participants, brachial-ankle pulse wave velocity (PWV) was significantly higher at baseline and follow-up. Only at follow-up was femoral-ankle PWV higher among Aβ-positive participants. There was no association between measures of central stiffness and blood pressure and Aβ status at baseline or follow-up. However, central stiffness was associated with a change in Aβ deposition over time, with each standard deviation increase in central stiffness (carotid-femoral PWV, P=0.001; heart-femoral PWV, P=0.004) linked to increases in Aβ deposition over two years.
"The association between Aβ deposition changes over time and generalized arterial stiffness indicated a relationship between the severity of subclinical vascular disease and progressive cerebral Aβ deposition," the authors write.
Several authors disclosed financial ties to the pharmaceutical and medical device industries.