Magnesium Sulfate Injection Rx

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Magnesium Sulfate Injection

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Generic Name and Formulations:

Magnesium sulfate 500mg/mL; soln for IM inj; or IV use after dilution; contains aluminum.

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Indications for Magnesium Sulfate Injection:

Magnesium deficiency.


Mild deficiency: 1g IM every 6 hours for four doses. Severe deficiency: 250mg/kg IM within a period of 4 hours if necessary; alternatively 5g may be added to one liter of 5% dextrose inj or 0.9% sodium chloride inj for slow IV infusion over a 3-hour period. TPN: usual range: 1–3g (8–24mEq) daily. Severe renal impairment: max 20g in 48 hours.


TPN for infants: usual range: 0.25–1.25g (2–10mEq) daily.


Heart block. Myocardial damage.


Renal impairment. Monitor serum magnesium levels; if repeated doses are given, test knee jerk reflexes before each dose. Have injectable calcium salt readily available to counteract magnesium intoxication. Elderly. Premature neonates. Pregnancy (Cat.D). Nursing mothers.


Additive CNS depressant effects with barbiturates, narcotics, other hypnotics; adjust dose. Potentiates neuromuscular blocking agents. Concomitant cardiac glycosides; use extreme caution, heart block may occur.

Adverse Reactions:

Magnesium intoxication (eg, flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and CNS depression proceeding to respiratory paralysis.


Formerly known under the brand name Sulfamag.

How Supplied:

Contact supplier.