Labor And Delivery
Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.
"Allowing women ad lib oral intake during labor does not increase adverse maternal or neonatal outcomes. It stands to reason that allowing such intake could increase patient satisfaction," the authors write.
Makena was the first FDA-approved treatment option for pregnant women who have had prior spontaneous preterm birth.
The researchers found that overall, 105,409 women received a hypertensive agent. Receipt of oral labetalol increased from 20.3% in 2006 to 31.4 percent in 2014 for all patients with preeclampsia.
The ASD group had a shorter duration of ultrasound exposure than the typical development group during the first (290.4 versus 406.4 seconds) and second (1,687.6 versus 2,011 seconds) trimesters. Greater mean depth of ultrasonographic penetration was seen in the ASD group versus the developmental delay group in the first trimester (12.5 versus 11.6 cm).
The researchers identified 993 neonates (2.6%) who received iNO among 37,909 neonates in the study sample. A total of 971 patients were included in each of the two matched cohorts.
On the other hand, a lower risk of preterm delivery was significantly associated with probiotic intake during early pregnancy but not before or during late pregnancy (adjusted odds ratio, 0.79).
The researchers found that live birth was more likely in women replete with vitamin D versus those with vitamin D deficiency or insufficiency.
After a pregnancy with eclampsia, a future seizure disorder was significantly more likely (4.58/10,000 person-years) compared with a pregnancy without a hypertensive disorder of pregnancy (0.72/10,000 person-years; crude hazard ratio [HR], 6.09).
The researchers found that the overall rate of SSI was 10.9% in the cohort. Overall, 6.4 and 15.4% of women in the cephalexin-metronidazole and placebo groups, respectively, were diagnosed with SSI (relative risk, 0.41).
In addition, the researchers assayed umbilical cord blood samples from 33 infants to assess the concentration of biologic agents.
Overall, the study points to an association between spontaneous abortion and influenza vaccination receipt in the past 28 days. This link, however, proved significant only among those vaccinated in the previous season with the pH1N1-containing vaccine.
The researchers observed no correlation for panic disorder or GAD with maternal or neonatal complications of interest, in adjusted models.
Researchers found a "surprisingly limited number of prospective studies" specifically addressing the question of whether consuming small amounts of alcohol has an impact on pregnancy and childhood outcomes.
Laboratory test results have indicated a lower than expected potency affecting certain lots which would lead to a lower dose being administered.
The researchers found that, overall, interventions were associated with a 9% reduction in risk of cesarean section, and a 24% reduction in risk of developing gestational diabetes.
The findings are particularly important because preeclampsia cases rose from 2.4% of pregnancies in 1980 to 3.8% in 2010, the researchers said.