Labor and Delivery

Increase Seen in Amphetamine Use in Pregnant Women

November 30, 2018

Amphetamine use was identified among about 1% of deliveries in the rural West by 2014 to 2015; this number was higher than the incidence of opioid use in most regions.

Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery

October 17, 2018

Although more than 3 million women give birth in the US each year, there is no consensus regarding the optimal timing of maternal pushing during the second stage of labor (defined as the time from complete cervical dilation to delivery of the fetus).

Timing of Pushing Does Not Impact Spontaneous Vaginal Delivery

October 10, 2018

The researchers found that the rate of spontaneous vaginal delivery was 85.9 and 86.5% in the immediate and delayed groups, respectively, with no significant difference.

Patient-Directed IV Remifentanil Cuts Epidural Conversions

September 20, 2018

"Intravenous remifentanil PCA halved the proportion of epidural conversions compared with intramuscular pethidine," the authors write. "This finding challenges routine pethidine use as standard of care in labor."

Folic Acid Past First Trimester Does Not Prevent Preeclampsia

September 14, 2018

The researchers found that preeclampsia occurred in 14.8 and 13.5% of women in the folic acid and placebo groups, respectively (relative risk, 1.10; 95% confidence interval, 0.90 to 1.34; P=.37).

Prophylactic Tranexamic Acid Does Not Cut Postpartum Bleeding

August 23, 2018

No significant drop in postpartum hemorrhage of 500 ml or more for women receiving oxytocin

Labetalol Use Up for Patients With Preeclampsia and Asthma

August 15, 2018

The researchers found that patients with asthma used carboprost less frequently than patients with no asthma (11.4 vs 18.0%) compared with intravenous labetalol, which was used more often among patients with a diagnosis of asthma than those without (18.5 vs 16.7%).

CDC: Rates of Opioid Use Disorder Seen at Time of Delivery Up

August 13, 2018

Rate of opioid use disorder at time of delivery quadrupled from 1999 to 2014

FDA: Improper Use of Rupture of Membranes Tests Linked to Fetal Deaths

By August 09, 2018

ROM tests are used to aid in diagnosing ruptured membranes in pregnant women through analysis of vaginal secretions.

Inducing Labor at Term Appears to Reduce Cesarean Risk

August 09, 2018

Elective induction at 39 weeks also linked to lower risk of maternal high blood pressure disorders

Eleven Infant Deaths Halt Trial of Sildenafil in Pregnant Women

July 25, 2018

Previous research in rats suggested that sildenafil might boost blood flow in the placenta and promote a baby's growth, The Guardian reported.

For Postpartum Hemorrhage, Carbetocin Similar to Oxytocin

July 05, 2018

Heat-stable carbetocin non-inferior for preventing blood loss of 500 ml, use of other uterotonic agents

Data Needed on New Type 2 Diabetes Therapies in Pregnancy

July 02, 2018

Scarce data on new glucose-lowering agents, with high risk for bias toward negative outcomes

Preservative-Free, Generic Version of Makena Now Available

By June 28, 2018

Hydroxyprogesterone Caproate is used to lower the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth.

No Causal Effect of 25(OH)D on Gestational HTN, Preeclampsia

June 21, 2018

"No strong evidence was found to support a causal effect of vitamin D status on gestational hypertension or preeclampsia," the authors write.

Antifungal Use During Pregnancy and Risk of Stillbirth: What's the Link?

By June 13, 2018

Based on the findings, it was concluded that fluconazole use during pregnancy was not associated with significantly increased risks of stillbirth or neonatal death. However, the authors cautioned that the confidence intervals were wide and neither result was statistically significant.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

By May 18, 2018

The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

CDC: Number of US Births Dropped to 30-Year Low in 2017

May 17, 2018

For teenagers aged 15 to 19 years, the birth rate decreased 7% in 2017 to 18.8 births per 1,000 women, with decreases in the rates for younger and older teenagers (15 to 17 and 18 to 19, respectively).

Acupuncture Doesn't Up Live Birth Rate for Women Having IVF

May 16, 2018

The researchers found that live births occurred in 18.3 and 17.8% of women receiving acupuncture and sham control, respectively (risk difference, 0.5% [95% confidence interval, −4.9 to 5.8%]; relative risk, 1.02 [95% confidence interval, 0.76 to 1.38]).

Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes

May 02, 2018

Frequency of primary outcome was 27.6 and 23.4 percent in glyburide and insulin groups, respectively

Fetal Inflammation May Play Role in Preterm Labor

April 26, 2018

T cells from preterm infants stimulated contractility of the uterine myometrium through interferon-γ and tumor necrosis factor-α. In mouse fetuses, adoptive transfer of activated T cells resulted in pregnancy loss.

ACOG: Revised Committee Opinion on Postpartum Care Released

By April 25, 2018

Previously, ACOG had recommended a comprehensive postpartum visit occur within the first 6 weeks after birth.

CDC: Birth Rate for 10- to-14-Year-Olds at Record Low in 2016

April 25, 2018

During the same time period, birth rates declined for females aged 10 to 14 years for all race and Hispanic-origin groups, with non-Hispanic black females having the largest decline.

Point-of-Care Test for Assessing Risk of Spontaneous Preterm Birth Approved

By April 20, 2018

The test detects placental alpha microglobulin-1 (PAMG-1) in patients presenting with signs and symptoms of preterm labor.

Cimzia Label Update Provides New Information for Women of Childbearing Age

By March 22, 2018

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

Is It Safe for Women to Eat or Drink During Labor?

March 01, 2018

"Allowing women ad lib oral intake during labor does not increase adverse maternal or neonatal outcomes. It stands to reason that allowing such intake could increase patient satisfaction," the authors write.

Ready-to-Use Makena Formulation Approved to Reduce Preterm Birth Risk

By February 15, 2018

Makena was the first FDA-approved treatment option for pregnant women who have had prior spontaneous preterm birth.

Antihypertensive Use During Delivery Evaluated Among Preeclamptic Women

February 15, 2018

The researchers found that overall, 105,409 women received a hypertensive agent. Receipt of oral labetalol increased from 20.3% in 2006 to 31.4 percent in 2014 for all patients with preeclampsia.

Is There Any Link Between Ultrasound Exposure and Autism?

February 14, 2018

The ASD group had a shorter duration of ultrasound exposure than the typical development group during the first (290.4 versus 406.4 seconds) and second (1,687.6 versus 2,011 seconds) trimesters. Greater mean depth of ultrasonographic penetration was seen in the ASD group versus the developmental delay group in the first trimester (12.5 versus 11.6 cm).