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Generic Name and Formulations:

Timolol (as maleate) 0.5%; oph soln; contains benzalkonium chloride.

Select therapeutic use:

Indications for ISTALOL:

Open-angle glaucoma. Ocular hypertension.


1 drop in affected eye(s) once daily in the AM.


Not recommended.


Greater than 1st-degree AV block. Overt cardiac failure. Cardiogenic shock. Sinus bradycardia. Bronchial asthma. Severe COPD. History of bronchospasm. Not for use as a sole agent in angle-closure glaucoma.


History of cardiac failure. Discontinue at 1st sign of cardiac failure, and before surgery. Avoid abrupt cessation. Diabetes. May mask hypoglycemia, thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Contact lenses (remove; may reinsert 15 min after instillation). Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Noncardioselective beta-blocker.


Avoid other topical β-blockers. May potentiate systemic β-blockers, reserpine, hypoglycemics, and mydriatic effect of topical epinephrine. May be potentiated by quinidine. May cause conduction defects with digoxin, calcium channel blockers (avoid concomitant use in impaired cardiac function).

Adverse Reactions:

Local irritation (burning, stinging), blurred vision, cataract, conjunctival injection, infection, headache, hypertension, itching. Systemic β-blocker effects (eg, bronchospasm, bradycardia, cardiac failure, muscle weakness).

How Supplied:


ISTALOL 2.5ml of 0.5% eye droppers (Qty:1)

appx. price $175.00