To better understand the impact of prior-season vaccination on subsequent influenza vaccine effectiveness, researchers conducted a multiseason, test-negative case-control study among vaccinated children 2-17 years old recruited during 3 influenza seasons (2013-2014, 2014-2015, and 2015-2016).
"This is the first new antiviral flu treatment with a novel mechanism of action approved by the FDA in nearly 20 years," said FDA Commissioner Scott Gottlieb, MD.
The vaccines are indicated for active immunization against influenza disease caused by virus subtypes A and type B present in the vaccine.
The New Drug Application for baloxavir marboxil is supported by results from the Phase 3 CAPSTONE-1 study (N=1436) which examined the effects of a single dose of baloxavir marboxil vs placebo or oseltamivir 75mg twice daily for 5 days.
MF59 adjuvanted, quadrivalent influenza vaccine (aQIV) was found to be more efficacious in preventing influenza than a non-adjuvanted conventional influenza vaccine in children aged 6 through 23 months.
To investigate a possible relationship, researchers from the University of Illinois and the Children's Hospital University analyzed 21,407 suicide-related events among 1 to 18 year old individuals.
The Advisory Committee on Immunization Practices (ACIP) has voted in favor of a renewed recommendation for the use of Flumist Quadrivalent (Influenza Vaccine Live, Intranasal).
So far this season, influenza A(H3N2) viruses have predominated, but other influenza viruses are also circulating.
As an expert in public health law, I can state two things with confidence. First, the U.S. has made enormous strides in preparing for and treating the flu. And second, we still are not nearly as prepared as we need to be for the next pandemic.
Results found that among portal users, 14% (702/5,000) of portal and IVR call recipients received EHR-documented influenza vaccines.
Severe influenza epidemics tend to occur every few decades. Experts believe that the next one is a question not of "if" but "when."
The supplemental Biologics License Application was based on a Phase III pivotal study of the efficacy of Fluarix Quadrivalent in children 6 months through 35 months of age and on two supportive studies.
VIS410, a monoclonal antibody, is being developed for single-dose administration to target all known strains of influenza A.
Overall, the study points to an association between spontaneous abortion and influenza vaccination receipt in the past 28 days. This link, however, proved significant only among those vaccinated in the previous season with the pH1N1-containing vaccine.
Data from a randomized, observer-blinded, comparator-controlled study (n=2,278) evaluating children aged 5-17 years showed that Afluria Quadrivalent vaccine was non-inferior to a comparator vaccine containing the same recommended virus strains.
For young people with egg allergy, live attenuated influenza vaccine (LAIV) is well tolerated, with low risk of systemic allergic reactions, according to a study published online December 8 in The BMJ.
A case study in Pediatrics describes the first published report of a potential oseltamivir-warfarin interaction in a child with influenza and hypoplastic left heart syndrome.