Infectious Diseases

Post-Endoscopic Infection More Common Than Previously Thought

June 22, 2018

The rates of infections were compared with those after screening mammography, prostate cancer screening, bronchoscopy, and cystoscopy procedures.

Acute Otitis Media Treatments

June 21, 2018

Acute otitis media treatment chart including select antibiotics and recommended doses.

CDC: Salmonella-Tainted Melon Outbreak Continues to Expand

June 21, 2018

Of the 63 patients with available information who became ill between, 34 have been hospitalized. No deaths have been reported. Illnesses have been reported in Illinois (7), Indiana (11), Kentucky (1), Michigan (38), Missouri (10), Ohio (2), and Tennessee (1).

Florida Teen First Human Case of Another Mosquito-Borne Virus

June 21, 2018

"This virus is part of a group commonly known as the California serogroup of viruses," first author, John Lednicky, PhD. "These viruses are known to cause encephalitis in several species, including humans."

Novel Antibiotic for <i>C. Difficile</i> Infection Gets FDA's QIDP Designation

By June 20, 2018

ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.

Should Physicians Treat Family and Friends? Three Experts Weigh In

By June 19, 2018

Although all of the guidelines acknowledge that there are emergent situations in which providing care for a family member or friend is not only permissible but also essential, other situations are frowned upon.

NDA Submitted for Novel, Targeted Antibiotic Iclaprim

By June 18, 2018

The NDA includes safety and efficacy data from two Phase 3 trials (REVIVE-1 and REVIVE-2; N=1190) which compared intravenous iclaprim to standard-of-care vancomycin in patients with ABSSSI.

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> Risk

June 18, 2018

The cereal under recall includes Honey Smacks 15.3 oz. size with the UPC code of 3800039103 and a Best if Used by Date of JUN 14, 2018, through JUN 14, 2019. Also included are Honey Smacks in the 23 oz. size with the same "Best Before" date and the UPC code of 3800014810.

Resistant <i>A. Baumannii</i> Rose in Children From 1999 to 2012

June 18, 2018

The researchers found that the crude proportion of cephalosporin-resistant (CephR) A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, with a peak of 32.5% in 2008. Similarly, the proportion of carbapenem(CR)-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012, peaking at 12.7% in 2008.

FDA Approves New Treatment for Onchocerciasis

By June 14, 2018

Moxidectin, a macrocyclic lactone, is an anthelmintic drug that selectively binds to the parasite's glutamate-gated chloride ion channels.

Sixty Sickened so Far in Salmonella-Tainted Melon Outbreak

June 14, 2018

Of the 60 patients who became ill between April 30, 2018, and May 30, 2018, 31 have been hospitalized. The patients range in age from 1 to 97 years.

Antifungal Use During Pregnancy and Risk of Stillbirth: What's the Link?

By June 13, 2018

Based on the findings, it was concluded that fluconazole use during pregnancy was not associated with significantly increased risks of stillbirth or neonatal death. However, the authors cautioned that the confidence intervals were wide and neither result was statistically significant.

Multilevel Interventions Needed to Improve Barriers to PrEP

By June 13, 2018

The final review included 47 articles that fell under 1 of the following categories: primary data on cognitive variables of providers; data on cognitive variables and perspectives of individuals at risk for HIV infection; literature on PrEP implementation; and case studies of PrEP demonstration and implementation projects.

Active Failures Seen in Proper Use of Personal Protective Equipment

June 12, 2018

Violations included entering rooms without some or all recommended PPE; during PPE removal, mistakes were frequently observed, as well as during encounters with challenging logistical situations, such as badge-enforced computer logins.

Kitchen Towels Are Source of Possibly Pathogenic Bacteria

June 12, 2018

Compared with single-use towels, multipurpose towels had higher colony-forming units (CFUs); humid towels had higher CFUs than dry ones. The mean CFU was 2.76 × 105, and was significantly higher from cotton versus nylon and mixture of both towels.

CDC: Invasive MRSA More Likely Among Injection Drug Users

June 12, 2018

The researchers found that the likelihood of developing invasive MRSA infections was 16.3 times higher for persons who inject drugs versus others.

Lengthy Viral Suppression May Cut Cancer Risk in HIV Infected

June 12, 2018

The researchers found that cancer incidence for HIV-positive vs uninfected persons was highest for unsuppressed persons (relative risk [RR], 2.35), lower among persons with early suppression (RR, 1.99), and lowest among persons with long-term suppression (RR, 1.52).

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

By June 11, 2018

Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.

HIV Pre-Exposure Prophylaxis Linked to Drop in Condom Use

June 07, 2018

Consistent condom use was reported by 46, 42, and 31% of men in 2013, 2016, and 2017, respectively (P<.001).

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

By June 07, 2018

Brincidofovir is the Company's lead candidate, a nucleotide analog that has antiviral activity against variola virus, which causes smallpox.

Post-Transplant Tx Reduces Wait for Kidney in Hep C&#43; Patients

June 07, 2018

In the post-transplant group, the median waitlist time was 122 days, which was significantly shorter than the center's regional and national wait time. There was no difference in allograft quality based on pathologic review or treatment-related adverse events between the two groups.

Prezcobix Not Recommended During Pregnancy, According to Updated Labeling

By June 05, 2018

The labeling now states that Prezcobix is not recommended for use in pregnant women due to substantially lower exposures of the active ingredients, darunavir and cobicistat, during pregnancy.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

By June 04, 2018

PJI is a challenging complication of joint arthroplasty with few effective treatment options.

CDC Says <i>E. Coli</i> Outbreak Tied to Romaine Lettuce Is Over

June 04, 2018

In total, 197 cases of illness tied to the E. coli O157:H7 strain of bacteria were linked to tainted romaine lettuce, with cases spread across 35 states.

FDA Issues Final Guidance on Inhalational Anthrax

June 01, 2018

The final guidance clarifies that drugs developed for inhalational anthrax prophylaxis can rely on evidence from animal studies (the Animal Rule) to support approval when the criteria under the Animal Rule have been met.

CDC: Administration Errors Reported With New Shingles Vaccine

By May 30, 2018

Between October 20, 2017 and February 20, 2018, the Vaccine Adverse Event Reporting System (VAERS) received 155 reports involving RZV, with 13 (8%) involving an administrative error.

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

By May 29, 2018

In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.

CDC IDs Outbreak Trends Tied to Treated Recreational Water

May 29, 2018

Overall, 24,453 cases were identified in the 363 outbreaks; 89, 4, and 3% were caused by Cryptosporidium, Pseudomonas, and Legionella, respectively.

Herpes Zoster Vaccination Rates Assessed Among People Living With HIV

By May 28, 2018

The authors found that vaccination rates varied between 1.5% and 42.4% at the 6 institutions assessed and that 21.3% of eligible patients at the University of Colorado received HZV prior to the intervention.

HCV Guidelines Updated to Include Recommendations for Key Populations

By May 25, 2018

The guidelines were developed by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America.