Genomic Medicine Will Help Shift Cardio Care to Proactive Approach

May 30, 2018

Genomic medicine will help shift clinical care from reactive to proactive, say the authors.

Raviten Gets Fast Track Status for Intradialytic Hypotension Management

By May 29, 2018

Intradialytic hypotension is a common complication of hemodialysis and can lead to increased morbidity and mortality among patients with end-stage renal disease.

Ob-Gyns Should Play Role in Reducing CVD Risk for Women

May 10, 2018

The authors note that most women consider their ob-gyn to be their primary care physician.

Giapreza Now Available to Up BP in Adults With Septic, Other Distributive Shock

By March 23, 2018

Giapreza, a vasoconstrictor, increases blood pressure through increased aldosterone release

Addition of Angiotensin II Improves Mortality in Severe Vasodilatory Shock

By February 26, 2018

Results showed that patients with a baseline APACHE II scores >30 had a significantly improved 28-day mortality trend in the angiotensin II group vs. the placebo group.

Giapreza Approved to Treat Critically Ill Hypotensive Patients

By December 26, 2017

In a clinical trial of 321 patients with shock and a critically low blood pressure, significantly more patients responded to treatment with Giapreza compared to those treated with placebo.

CDC: Heart Disease, Hearing Loss Screening Overlooked for Many Newborns

August 29, 2017

"Newborn screening at birth is crucial to quickly identify infants at risk of hearing loss and congenital heart disease so they can receive early intervention and follow-up care," Brenda Fitzgerald, MD, director of the CDC.

Orthostatic Hypotension Guidelines Called into Question

By July 31, 2017

After adjustments, measurement 1 was significantly associated with risk of fall (HR 1.22, 95% CI: 1.03-1.44), fracture (HR 1.16, 95% CI: 1.01-1.34), syncope (HR 1.40, 95% CI: 1.20-1.63), and death (HR 1.36, 95% CI: 1.23-1.51). Measurement 2 was associated with all long-term outcomes, including motor vehicle crashes (HR 1.43, 95% CI: 1.04-1.96).

Angiotensin II Treatment Examined in Vasodilatory Shock

May 24, 2017

Researchers randomized patients with vasodilatory shock receiving more than 0.2 µg of norepinephrine/kg body weight/minute or equivalent dose of another vasopressor to receive angiotensin II or placebo infusions.

Self-Administered Nasal Spray Examined for Paroxysmal SVT

May 15, 2017

The researchers found heart rate was controlled within 15 minutes in 87% of patients who received a 70-mg dose of the nasal spray; 75% of patients who got 105-mg; and 95% of patients given a 140-mg dose.

More Intensive Alveolar Strategy May Benefit Cardiac Sx Patients

March 23, 2017

The mean and median pulmonary complications score was 1.8 and 1.7, respectively, for the intensive recruitment strategy group, compared with 2.1 and 2.0, respectively, for the moderate strategy group.

Drug Shortage Linked to Increased Death in Patients with Septic Shock

By March 21, 2017

Higher rates of septic shock deaths occurred during quarters of norepinephrine shortage.

How Often is Orthostatic Hypotension a Risk Factor in Incident Falls?

March 21, 2017

The researchers observed an increased relative risk of UF with impaired orthostatic BP stabilization at 40 seconds after standing (OH[40]) (relative risk, 1.52).

Orthostatic Hypotension and Dementia: What's the Link?

March 13, 2017

Middle-aged adults found 40 percent more likely to develop dementia over time

Nipride RTU Approved for Immediate BP Reduction

By March 10, 2017

Nipride RTU is approved for immediate blood pressure reduction and also carries a Boxed Warning describing the possibility of excessive hypotension and cyanide toxicity.

Drug for Catecholamine Resistant Hypotension Shows Promise in Phase 3 Study

By February 27, 2017

La Jolla announced positive data from the ATHOS-3 study which evaluated LJPC-501 (angiotensin II) for the treatment of catecholamine resistant hypotension (CRH).

New Warning Added to Antipsychotic Drug Labeling

By February 27, 2017

The FDA has approved updates to all antipsychotic medication labels to specifically warn of somnolence, postural hypotension, and motor and sensory instability risks.

Hypotension Drug Gets FDA Approval

By February 01, 2017

The Food and Drug Administration (FDA) has approved Corphedra (ephedrine sulfate injection; Par) for the treatment of clinically important hypotension occurring in the setting of anesthesia.

Hormone ID'd as Link Between Bone and Vascular Disease

January 11, 2017

Significant association with carotid-femoral pulse wave velocity persists after multivariable adjustment

New Link Found Between Orthostatic Hypotension and Dementia

October 12, 2016

There is an association between orthostatic hypotension and an increased risk for dementia, according to a new study published online October 11 in PLOS Medicine.

Levosimendan Investigated in Patients with Septic Shock

October 07, 2016

Drug also tied to lower odds of successful weaning from mechanical ventilation in adults with sepsis

Orthostatic Hypotension Drug Updated with New Warnings

By October 05, 2016

Hypersensitivity reactions including anaphylaxis, angioedema, bronchospasm, urticaria and rash have been reported in postmarketing experience.

Sterility Concerns with Phenylephrine HCI Injection Prompt Recall

By September 01, 2016

Sandoz announced a voluntary recall of four lots of Phenylephrine HCI Injection, USP, 10mg/mL, 5mL and 10mL vials due to concerns of product sterility during an inspection at Allergy Laboratories, Inc.

Vasopressin: An Effective First-Line Option for Septic Shock?

By August 03, 2016

In adults with septic shock, early vasopressin use vs. norepinephrine did not improve the number of kidney failure-free days, a study in JAMA concluded.

Droxidopa Effective, Safe for Symptomatic NOH Across Age Groups

By April 20, 2016

Use of the norepinephrine oral prodrug, droxidopa, for the treatment of symptomatic neurogenic orthostatic hypotension is effective and "generally well tolerated across a range of ages," including in those 75 years and older.

A Dose of His Own Medicine Leaves Patient With a Bad Taste in His Mouth

By February 24, 2016

This is only the second reported case of these rare adverse events occurring with this cardiovascular agent.

Critical Care Drug Recalled After Discoloration Complaints

By January 04, 2016

PharMEDium Services, LLC announced a voluntary recall of 29 lots of 4mg Norepinephrine Bitartrate (16mcg/mL) added to 0.9% Sodium Chloride in 250mL Viaflex Bag and 3 lots of 8mg Norepinephrine Bitartrate (32mcg/mL) added to 0.9% Sodium Chloride in 250mL Viaflex Bag.

The Impact of Low Blood Sugar on the Heart

By November 04, 2015

In a new study published in Diabetes, researchers examined the effects of hypoglycemia on cardiovascular autonomic control and found that there is a clear change in the body's responses to cardiovascular stress.

Resting Heart Rate Linked to Risk of Violent Behavior

By September 09, 2015

An increased risk for violent criminality in males was seen in those with a low resting heart rate in late adolescence, an article published in JAMA has shown.

Time to Restarting BP Meds Post-Op Could Impact Outcomes

By June 04, 2015

Resuming treatment with angiotensin receptor blockers (ARBs) within two days following surgery is associated with reduced mortality rates in the first month post-surgery, reports a new study in the journal Anesthesiology.