There was a significant increase in statin prescribing in the active choice with peer comparison arm compared with usual care.
Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.
The new rule allows pharmacists to prescribe medications for cold sores, seasonal influenza, strep throat, and urinary tract infections, as well as statins for patients with diabetes.
Multiple studies have indicated that the 2013 PCEs - published by the American College of Cardiology/American Heart Association Task Force on Practice Guidelines - substantially misestimated CVD risk.
For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.
AKI was independently associated with higher rates of the composite outcome of hospitalization for heart failure and atherosclerotic events 1-year post-discharge.
Antisense technology refers to the use of synthetic nucleic acid sequences to interrupt specific protein production by targeting the corresponding messenger RNA that encodes that protein.
Doses of Zypitamag >4mg once daily were associated with an increased risk for severe myopathy in premarketing clinical studies, therefore dosing should not exceed 4mg once daily.
Women were less likely to fill a high-intensity statin than men overall, among those with no prior statin use, among those taking low/moderate-intensity statins prior to MI, and among those taking high-intensity statins prior to their MI.
Statin-associated muscle pain can hinder medication adherence which could potentially lead to an increased risk of cardiovascular events.
Among adults with definite/probable FH or severe dyslipidemia, the frequency of cholesterol screening and awareness was high (>80%); statin use was uniformly low among adults with definite/probable FH and with severe dyslipidemia (52.3 and 37.6%, respectively).
After classifying patients into 5 groups based on their blood linoleic level, the researchers found a 43% reduced risk of premature death among those with the highest level when compared with the group with the lowest level (adjusted hazard ratio [HR] 0.57, 95% CI: 0.46, 0.71; P<0.00).
Use of ticagrelor resulted in similar rates of major bleeding compared to clopidogrel in patients with ST elevation myocardial infarction treated with thrombolysis.
The ODYSSEY Outcomes trial (N=18,924) evaluated the effect of alirocumab on the occurrence of MACE in patients who had an ACS between 1-12 months prior to trial enrollment, and who were already taking maximally-tolerated statins (atorvastatin or rosuvastatin).
For this study, researchers aimed to determine the impact of statin use on the risk of nephrolithiasis and to assess whether higher lipid levels were associated with the risk of stone formation.
For this review, researchers performed an extensive literature search for studies and cases where an adverse drug reaction occurred likely due to an interaction between an herbal and a prescribed medicine.
In both yoga groups there was an increase in brachial artery flow-mediated dilation (P<0.05). In the time-control group there were no significant changes in any outcome variables.
Diagnostic confirmation via genetic testing or meeting minimum clinical scores/criteria was required for patients with familial hypercholesterolemia.
High levels of agreement between statin eligibility found between several guidelines included in this study
The researchers found that the rate of MACE was higher with the presence of high-risk plaque (6.4 versus 2.4%; hazard ratio, 2.73).
International Laboratories, LLC is notifying distributors and customers by letter and is arranging for return of all recalled products.
"Guidelines recommending that more persons use statins for primary prevention of ASCVD should prevent more events than guidelines recommending use by fewer persons," the authors write.
Ninety-three of the 99 patients taking AT medication continued their normal regimen through surgery and were included in the analysis.