For this study, researchers searched several large databases (from 1980 to 2016) for randomized, controlled trials (RCTs) that compared clinical outcomes in patients on DAPT taking PPIs or H2RAs.
There is a lack of evidence for efficacy of pharmacologic agents and emerging evidence of significant harm; consequently, these agents should be used sparingly, if at all.
The researchers found that the mean DeMeester score was 44 ± 33 for GERD+ and 7 ± 4 for GERD−. For GERD+ and GERD−, the mean HADS scores for anxiety (8 for both; P=0.2) and depression (5 and 6, respectively; P=.3) did not differ significantly.
According to the review, a substantial number of patients can effectively decrease or completely discontinue use of PPIs, as often these agents are prescribed without an appropriate reason.
The Reza Band is worn around the neck while sleeping and applies slight external pressure to the cricoid cartilage area, which increases the internal pressure of the upper esophageal sphincter (UES).
The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.
Use of histamine 2 receptor antagonists (H2RA) or proton pump inhibitors (PPIs) during the first 6 months of life was associated with increased risk of allergic disease and asthma.
The researchers found that 7.6% of included children were prescribed a histamine-2 receptor antagonist (H2RA), 1.7 percent a proton pump inhibitor (PPI), and 16.6% an antibiotic during the first 6 months of life.
The result comparisons found an overall agreement in the pre-therapy cohort between the breath test and the reference biopsy result of 98.3% (95 CI: 95.2%-99.7%).
Patients with functional heartburn display similar symptoms seen in GERD and most often complain of a burning retrosternal discomfort. Once the underlying cause of a patient's refractory heartburn is determined, appropriate therapy can be initiated.
Among participants ≤45 years in the H. pylori-positive group, the prevalence of gallstones was lower than in the H. pylori-negative group (odds ratio, 0.653).
Results showed that PPI use correlated with elevated risk of GC (hazard ratio, 2.44; 95% confidence interval, 1.42 to 4.2), while histamine-2 receptor antagonist use was not associated with increased risk (hazard ratio, 0.72; 95% confidence interval, 0.48 to 1.07).
The case involved a 32-year-old male who was prescribed pantoprazole after initially presenting with dyspepsia-like symptoms.
After adjustment for age, sex, comorbidities, and concomitant medications, the rates of ischemic stroke and MI were significantly increased with current PPI exposure (hazard ratios, 1.13 and 1.31).
From 2000 to 2016 there was little change in the extent of appropriate PPI use reported in 34 international studies. Patient-centered deprescribing, academic detailing, educational programs, and safety notifications were interventions for addressing inappropriate use.
In this retrospective study, researchers from New York Medical College, Valhalla, NY, compared the efficacy of diet-based treatment consisting of alkaline water (pH >8.0) and plant-based Mediterranean-style diet vs. the conventional PPI approach.
Both the 150mg and 300mg strengths are available as a generic; the 150mg strength is also available over-the-counter.
After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.
Addition of bismuth subcitrate to levofloxacin-based triple tx no more effective for H. pylori infection
The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).
The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).
Nephron Pharmaceuticals has joined the effort to abate the nationwide shortage of Sodium Bicarbonate 8.4% by tripling its production of the injectable syringes.
While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.
A retrospective cohort study looked at 786 patients with dementia and new PPI usage and 786 matched patients with dementia without PPI usage.