Hyperacidity/GERD/ulcers

Review: Managing Patients With Refractory Heartburn

By February 01, 2018

Patients with functional heartburn display similar symptoms seen in GERD and most often complain of a burning retrosternal discomfort. Once the underlying cause of a patient's refractory heartburn is determined, appropriate therapy can be initiated.

Links Between Bacterial Infection and Gallbladder Disease Investigated

December 18, 2017

Among participants ≤45 years in the H. pylori-positive group, the prevalence of gallstones was lower than in the H. pylori-negative group (odds ratio, 0.653).

PPI Use May Up Gastric Cancer Risk Even After <i>H. Pylori</i> Eradication Tx

November 02, 2017

Results showed that PPI use correlated with elevated risk of GC (hazard ratio, 2.44; 95% confidence interval, 1.42 to 4.2), while histamine-2 receptor antagonist use was not associated with increased risk (hazard ratio, 0.72; 95% confidence interval, 0.48 to 1.07).

Proton Pump Inhibitor Use Linked to Two Distinct Dermatological Reactions

By October 18, 2017

The case involved a 32-year-old male who was prescribed pantoprazole after initially presenting with dyspepsia-like symptoms.

PPI Use and First-Time Stroke, MI: What's the Link?

October 18, 2017

After adjustment for age, sex, comorbidities, and concomitant medications, the rates of ischemic stroke and MI were significantly increased with current PPI exposure (hazard ratios, 1.13 and 1.31).

PPI Effectiveness Compared for Erosive Esophagitis Management

By September 28, 2017

The researchers chose endoscopic healing rates (at 4 and 8 weeks) as the primary efficacy outcome.

Best Practice Recs for <i>H. pylori</i> Treatment Reviewed

By September 22, 2017

The authors stated that the recommended approach should be based on local and individual antibiotic resistance patterns.

PPIs Should Be Focus for Deprescribing, Says New Research

September 20, 2017

From 2000 to 2016 there was little change in the extent of appropriate PPI use reported in 34 international studies. Patient-centered deprescribing, academic detailing, educational programs, and safety notifications were interventions for addressing inappropriate use.

Diet May Be as Effective as PPIs in Reducing Reflux Symptoms

By September 07, 2017

In this retrospective study, researchers from New York Medical College, Valhalla, NY, compared the efficacy of diet-based treatment consisting of alkaline water (pH >8.0) and plant-based Mediterranean-style diet vs. the conventional PPI approach.

Prescription Strength Acid-Suppressing Agent Soon to Be Unavailable

By September 05, 2017

Both the 150mg and 300mg strengths are available as a generic; the 150mg strength is also available over-the-counter.

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

Bismuth-Based Quad Tx Compared to Levofloxacin Triple Tx for <i>H. pylori</i> Infection

July 14, 2017

Addition of bismuth subcitrate to levofloxacin-based triple tx no more effective for H. pylori infection

Proton Pump Inhibitor Use May Up Death Risk

By July 05, 2017

The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).

Do PPIs Increase the Risk of Dementia?

By June 22, 2017

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

Nephron Pharma Responds to Sodium Bicarbonate Shortage

By June 22, 2017

Nephron Pharmaceuticals has joined the effort to abate the nationwide shortage of Sodium Bicarbonate 8.4% by tripling its production of the injectable syringes.

Sodium Bicarbonate Syringe Availability Announced in Response to Shortage

By June 20, 2017

QuVa will be supplying Sodium Bicarbonate PF 8.4% to both current and new customers.

<i>H. Pylori</i> Treatment May Also Improve This Skin Condition

May 08, 2017

Significant decrease in most criteria of rosacea Duluth score in patients cured of H. pylori infection

AGA: Best Practices for Prescribing PPIs

By April 07, 2017

While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.

PPI Use Significantly Increases Pneumonia Risk in Dementia

March 30, 2017

A retrospective cohort study looked at 786 patients with dementia and new PPI usage and 786 matched patients with dementia without PPI usage.

Acid Suppressants May Up Risk of Recurrent CDI

By March 27, 2017

It may be prudent to assess the need for gastric acid suppressants in patients with CDI, the authors state.

Anti-Reflux Meds May Improve Nasal Symptoms in LPR

March 14, 2017

Decrease in median total nasal resistance score and Nasal Obstruction Symptom Evaluation Score

GERD Treatment May Reduce Healthcare Visits for Acute Respiratory Infections

By February 22, 2017

This population-based study included 21,486 patients diagnosed with GERD and 21,486 matched comparison patients without GERD.

Study Reveals Most Common Drug Interactions Among Older Patients

By January 24, 2017

Findings from a cross-sectional study show that drug interactions are common among community-dwelling older adults and are related to the number of medications and hospitalization in the previous year.

Do PPIs Protect Against Dysplasia, Cancer in Barrett's Esophagus?

By January 11, 2017

In patients with Barrett's esophagus, use of proton pump inhibitors (PPIs) did not lead to dysplasia- or cancer-protective effects.

Is Heartburn Med Use During Pregnancy Tied to Child's Asthma Risk?

By January 09, 2017

Use of acid suppressing agents during pregnancy may increase the risk of asthma in the offspring, according to a study published in The Journal of Allergy and Clinical Immunology.

Quality of Life Assessed in Laryngopharyngeal Reflux

January 09, 2017

For patients with gastroesophageal reflux disease (GERD), the presence of laryngopharyngeal reflux symptoms (LPR) is associated with reduced health-related quality of life (HRQoL), according to a study published online in the Journal of Gastroenterology and Hepatology.

Do Acid Suppression Drugs Up Bacterial Gastroenteritis Risk?

By January 05, 2017

The use of acid suppression medicines was associated with higher rates of Clostridium difficile and Campylobacter positive gastroenteritis in both community and hospital settings, according to a study published in the British Journal of Clinical Pharmacology.

Impact of Anticholinergic Drugs Should Be Considered in Older Patients

January 03, 2017

Anticholinergic medications are frequently prescribed to older adults, but their negative impact should be considered, according to a review published online December 23 in the Journal of Pharmacy Practice and Research.

Significant Number of Preemies Receive Gastroesophageal Reflux Meds

November 30, 2016

Seventy-seven percent of those on medications started after NICU discharge; prolonged use common

PPI Use Tied to Increased Risk of Gastric Polyps

November 28, 2016

Long-term proton pump inhibitor (PPI) use is associated with increased risk of fundic gland polyps (FGPs).