Declining estrogen levels during menopause can contribute to the development of menopause-related vasomotor symptoms (VMS), such as hot flashes and night sweats. Moderate to severe VMS can significantly reduce quality of life and have substantial effects on physical and emotional well-being. Although hormone therapy is considered the most effective treatment for VMS, many women either refuse hormone therapy or have contraindications to it. This article discusses treatment approaches and considerations surrounding the 2 approved nonhormonal therapies for moderate to severe VMS.
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