Robert Montgomery, MD, professor of surgery and director of the Comprehensive Transplant Center at Johns Hopkins, gives an in-depth interview on kidney transplants, from the causes of renal failure to dialysis and its challenges to the various issues associated with transplantation. Dr. Montgomery discusses altruistic donors, incompatible donation, and the “domino chain” method of allowing for the most transplants possible that has been developed, along with new methods for donation from incompatible sources.