What causes epilepsy?
Six out of 10 people have idiopathic epilepsy, that is, epilepsy of no known cause. Symptomatic epilepsy has an identifiable cause such as brain damage at birth, a stroke, meningitis or very occasionally, a brain tumor. The tendency for seizures can run in families.

Most seizures can occur at any time but in some people with epilepsy, seizures can be triggered by certain events. Common triggers include: stress; anxiety or excitement; late nights and lack of sleep; illness; hormonal changes, such as at puberty, menopause and pregnancy; diet, particularly a lack of food leading to low blood sugar; and alcohol. About 5% of people with epilepsy are affected by patterns of light such as on a TV screen or when playing video games.

It is possible to suffer a seizure that is not caused by epilepsy. Young children and babies can have febrile convulsions that are caused by high fevers rather than epilepsy. Long-term abuse of alcohol can also cause seizures.

What tests confirm a diagnosis of epilepsy?
A single seizure does not necessarily indicate epilepsy, but if you have more than one, you will be referred to a neurologist who may arrange a number of painless tests. An electroencephalogram (EEG) monitors the electrical activity of your brain. It takes less than 30 minutes and indicates the activity in the brain at that particular time. Sometimes you may be given a small monitor to measure your brain waves over 24 hours. This is known as ambulatory monitoring. A computerized tomographic (CT) scan can show up any areas of damage to the brain that could be causing the epilepsy. A magnetic resonance imaging (MRI) scan is a more sophisticated version of a CT scan. In addition, a blood sample will usually be taken to check your overall health and to look for any other possible causes of the epilepsy.

How is epilepsy treated?
Drug therapy can control seizures completely in up to 80% of people. It may be necessary to take the medication(s) for a number of years, but treatment can often be stopped when you have been free from seizures for two or more years. Treatment must not be stopped suddenly as this can trigger a seizure. Your doctor will wean you off your medicine slowly to prevent this.
For a few people, drug treatment is not able to control their epilepsy completely, but is still beneficial in preventing some seizures. Neurosurgery may be a possibility for those people whose epilepsy is caused by an abnormality in one particular area of the brain.

The dosages of drugs given need to be adjusted to individual patients in order to avoid unwanted side effects such as drowsiness. The ideal dosage is the lowest dose necessary to stop the seizures occurring. Drugs that may be given include carbamazepine (Tegretol), clonazepam (Klonopin), ethosuximide (Zarontin), gabapentin (Neurontin), lamotrigine (Lamictal), oxcarbazepine (Trileptal, Oxtellar XR), phenytoin (Dilantin), primidone (Mysoline), valproate sodium (Depacon), acetazolamide (Diamox), tiagabine (Gabitril), topiramate (Topamax), valproic acid (Depakene, Stavzor), divalproex sodium (Depakote), vigabatrin (Sabril), levetiracetam (Keppra), pregabalin (Lyrica), mephobarbital (Mebaral), ezogabine (Potiga), lacosamide (Vimpat) and zonisamide (Zonegran).

Regular check-ups are necessary in people taking long-term drug therapy. These may be carried out in hospital for people whose epilepsy is difficult to control.

Self-help measures

  • Try to avoid the known trigger factors for seizures. This may mean eating regular meals, trying to control stress, avoiding becoming overtired, and taking your medication regularly.
  • Always tell the pharmacist you are taking medication for epilepsy before buying over-the-counter (OTC) medicines. Some of these can interact with your treatment.
  • If your epilepsy cannot be controlled completely, try to think about safety in your surroundings and possible changes you can make.
  • Try not to let epilepsy prevent you from doing everyday things in your life, most people with epilepsy lead full and active lives.

Further information
Epilepsy Foundation: www.epilepsyfoundation.org

Last Reviewed: June 2013