Vitamin D supplementation could help children with mild-to-moderate chronic kidney disease (CKD) in reducing the risk of renal failure progression, according to a study published in the Journal of the American Society of Nephrology (JASN).

Previous research has suggested that vitamin D may assist in blocking the renin-angiotensin-aldosterone system (RAAS) in adults. Rukshana Shroff, MD, PhD, from the Great Ormond Street Hospital for Children in London, and colleagues sought to determine whether 25-hydroxyvitamin D influences CKD progression in 167 children based on long-term data from the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) trial.

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Five-year kidney survival was 75% in the patients with vitamin D levels ≥50 nMol/L at the beginning of the study and 50% in those with lower levels. Those with lower vitamin D levels had greater levels of blood markers linked to kidney dysfunction, along with greater kidney function loss over time.

Based on these results, Dr. Shroff recommends that clinical trials be conducted on the vitamin D supplement cholecalciferol in children with CKD.

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