The DNA vaccine works like an ACE inhibitor medication, that relaxes and opens up blood vessels, by targeting the hormone angiotensin II. In the study, hypertensive rats were immunized three times at two-week intervals with needleless injections. Researchers found that the vaccine lowered blood pressure for up to six months and reduced tissue damage to the heart and blood vessels. There were no signs of damage to organs such as the kidney or liver.
A DNA vaccine for hypertension may be an effective way to control noncompliance among patients. Also, it may be a cheaper treatment option in countries where antihypertensive drugs are expensive, researchers concluded.
For more information visit Heart.org.