HealthDay News – Acute treatment of migraine with ubrogepant leads to significantly greater rates of pain freedom at 2 hours than placebo, according to a study published online November 19 in the Journal of the American Medical Association.

Richard B. Lipton, MD, from the Albert Einstein College of Medicine in Bronx, New York, and colleagues conducted a phase 3 multicenter trial involving adults with migraine with or without aura experiencing 2 to 8 migraine attacks per month. Participants were randomly assigned to either ubrogepant 50mg (562 participants), ubrogepant 25mg (561 participants), or placebo (563 participants) for a migraine attack of moderate or severe pain intensity.

The researchers found that pain freedom at two hours was reported by 21.8, 20.7, and 14.3% of participants in the ubrogepant 50mg, ubrogepant 25mg, and placebo groups, respectively (absolute difference for 50mg vs placebo, 7.5% [95% confidence interval (CI), 2.6 to 12.5%; P =.01]; absolute difference for 25mg vs placebo, 6.4% [95% CI, 1.5 to 11.5%; P =.03]). Absence of the most bothersome associated symptom at 2 hours was reported by 38.9, 34.1, and 27.4% of participants in the ubrogepant 50mg, ubrogepant 25mg, and placebo groups, respectively (absolute difference for 50mg vs placebo, 11.5% [95% CI, 5.4 to 17.5%; P =.01]; absolute difference for 25mg vs placebo, 6.7% [95% CI, 0.6 to 12.7%; P =.07]).

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“Further research is needed to assess the effectiveness of ubrogepant against other acute treatments for migraine and to evaluate the long-term safety of ubrogepant among unselected patient populations,” the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Allergan, which manufactures ubrogepant and funded the study.

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