AstraZeneca has announced that wholesale ordering restrictions in place for Toprol-XL (metoprolol succinate) extended-release tablets have been removed and that supply levels of Toprol-XL are approaching near usual levels. AstraZeneca instituted a short-term order management system to wholesalers to ensure equitable distribution of Toprol-XL after two generic companies recalled or suspended shipments of metoprolol succinate in late 2008 and early 2009. The system has been lifted as AstraZeneca is now manufacturing and distributing enough Toprol-XL and metoprolol succinate to meet historical demand levels. The authorized generic is distributed and marketed by Par Pharmaceutical.

Toprol-XL is indicated for the treatment of hypertension, alone or in combination with other antihypertensives; the long-term treatment of angina pectoris; and the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin.

For more information call (800) 236-9933 or visit www.toprolxl.com.