Testosterone replacement therapy did not improve sexual function males with ejaculatory disorders and low testosterone levels, data from a new study showed. Findings from the study are published in the Journal of Endocrinology & Metabolism.
In this first clinical study examining the treatment of ejaculatory disorder, researchers conducted a multi-center, double-blind, randomized, placebo-controlled 16-week trial (n=76) in men with ejaculatory dysfunction with testosterone levels <300ng/dL. Participants were randomized to either a 2% topical testosterone solution or a placebo. Testosterone levels were measured periodically to determine efficacy of hormone replacement therapy, and ejaculatory function was assessed through semen sample collection and sexual health questionnaires and logs.
Men who received testosterone replacement therapy did score higher on the questionnaire on ejaculatory dysfunction than men who received placebo but the difference was not statistically significant. There was also no or little improvement in ejaculate volume or orgasmic function. About 70% of those who used topical testosterone solution achieved testosterone levels >300ng/dL but improvement in ejaculatory function when compared to men who did not reach this threshold was not statistically significant.
Researchers concluded that testosterone therapy was not effective for all the men who received it. Clinicians should consider other reasons for delayed ejaculation other than hypogonadism, they added.
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