HealthDay News – Testosterone replacement is associated with an improvement in body composition among younger male cancer survivors with low-normal morning total serum testosterone, according to a study published online November 12 in PLOS Medicine.

Jennifer S. Walsh, MB ChB, PhD, from the University of Sheffield in the United Kingdom, and colleagues randomly assigned (1:1) 136 male survivors of testicular cancer, lymphoma, and leukemia (aged 25 to 50 years) to receive either testosterone (Tostran 2 percent gel) or placebo for 26 weeks. Participants all had morning total serum testosterone of 7 to 12nmol/L and were matched for body mass index.

The researchers found that at the end of the trial, testosterone treatment was associated with decreased trunk fat mass (−0.9kg; 95% CI, −1.6 to −0.3; P =.0073), decreased whole-body fat mass (−1.8kg; 95% CI, −2.9 to −0.7; P =.0016), and increased lean body mass (1.5kg; 95% CI 0.9 to 2.1; P <.001) compared with placebo. The greatest decrease in fat mass was seen in patients with a high truncal fat mass at baseline. No association was seen between treatment effect and physical function or any other quality of life scores.

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“The results of this study have significant benefits alongside improvements in body composition, potentially offsetting the risk of increased mortality from heart disease,” a coauthor said in a statement.

Several authors disclosed financial ties to pharmaceutical and diagnostic companies.

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