(HealthDay News) – The pneumococcal conjugate vaccine containing 10 serotype-specific polysaccharides conjugated to Haemophilus influenza protein D, tetanus toxoid, and diphtheria toxoid as the carrier proteins (PHiD-CV10) is effective against invasive pneumococcal disease, including in infants using a 2+1 schedule, according to a study published online Nov. 16 in The Lancet.
Arto A. Palmu, MD, from the National Institute for Health and Welfare in Tampere, Finland, and colleagues conducted a cluster-randomized trial in which children aged <19 months received PHiD-CV10 in 52 clusters or hepatitis vaccines as control in 26 clusters. A 3+1 or a 2+1 vaccination schedule was used in infants <7 months at the first vaccination. A 2+1 schedule was used in children aged 7–11 months, and those 12–18 months of age received a two-dose schedule.
The researchers found that, of the 30,528 participants assessed for the primary objective, 13 culture-confirmed vaccine-type cases of invasive pneumococcal disease were detected (none in the PHiD-CV10 3+1 group; one in the PHiD-CV10 2+1 group; and 12 in the control groups). For PHiD-CV10 3+1, the vaccine effectiveness was estimated at 100%, and 92% effectiveness was estimated for PHiD-CV10 2+1. In combined PHiD-CV10 infant cohorts there were two cases of any culture-confirmed invasive disease, compared with 14 in the corresponding control cohorts (vaccine effectiveness 93%). Seven cases of invasive disease were reported in catch-up cohorts, all of which were in the control group.
“This nationwide trial showed high PHiD-CV10 effectiveness against invasive pneumococcal disease when given in different schedules,” the authors write. “For the first time, effectiveness of a 2+1 schedule in infants was confirmed in a clinical trial.”
Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which in part funded the study.