HealthDay News — Most untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions regress, especially among women younger than 30 years, according to a review published online February 27 in The BMJ.

Karoliina Tainio, MD, from the University of Helsinki in Finland, and colleagues conducted a systematic review and meta-analysis to estimate the regression, persistence, and progression of untreated CIN2 lesions managed conservatively. Data were included from 36 studies with 3,160 women. 

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The researchers found that the pooled rates were 50% for regression, 32% for persistence, and 18% for progression at 24 months. The rates were 60, 23, and 11%, respectively, in a subgroup analysis of 1,069 women aged younger than 30 years. In prospective studies, the rate of non-compliance was about 10%. 

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“Most CIN2 lesions, particularly in young women (<30 years) regress spontaneously,” the authors write. “Active surveillance, rather than immediate intervention, is therefore justified, especially among young women who are likely to adhere to monitoring.”

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