Testosterone replacement therapy (TRT) could also lead to cardiovascular benefits, as new research in the European Heart Journal on over 83,000 men discovered that normalization of total testosterone (TT) levels with TRT led to fewer heart attacks and strokes.
The retrospective study assessed 83,010 male patients who received their medical care at the Veterans Health Administration (VHA) from December 1999 to May 2014 with documented low total testosterone (TT) levels. Unlike other studies that have evaluated TRT and cardiovascular events, participants were excluded if they had a documented myocardial infarction (MI) or stroke prior to the assessment of their TT levels. The patients were categorized as receiving TRT with resulting normalization of TT levels (normalized-TRT), TRT without normalization of TT levels (non-normalized-TRT), or did not receive TRT (no-TRT).
All-cause mortality, risk of MI, and stroke were significantly lower in the normalized-TRT group compared to the no-TRT group. There was no difference in MI or stroke risk between the non-normalized-TRT and no-TRT groups. The authors stated that normal testosterone levels could benefit cardiovascular health on adipose tissue, insulin sensitivity, and lipid profiles or by its anti-inflammatory and anticoagulant properties, but there could also be other potential mechanisms such as sodium retention or increased platelet aggregation.
For more information visit VA.gov.