A study published in Clinical, Cosmetic, and Investigational Dermatology showed that TriCalm hydrogel is significantly superior to diphenhydramine 2% and hydrocortisone 1% in its antipruritic effect.

In the double-blinded, vehicle-controlled, randomized, crossover study, TriCalm was tested for its antipruritic effect in reducing intensity and duration of itch and to compare its effectiveness against typical antipruritis products containing diphenhydramine 2% and hydrocortisone 1%. The study evaluated 48 healthy participants before and after treatment with TriCalm hydrogel, diphenhydramine 2%, and hyrdrocortisone 1%, and a hydrogel vehicle (control).

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TriCalm demonstrated the highest itch reduction in itch intensity, itch duration, and total itch perceived. TriCalm was also six times more effective than diphenhydramine 2% and eight times more effective than hydrocortisone 1% at lowering the sensation of itch on the participants’ skin.

TriCalm is an over-the-counter steroid-free topical hydrogel for itch relief. Its mechanism is induced via the PAR2 pathway.

For more information visit TriCalm.com.