HealthDay News — Among patients with surgically managed orthopedic fractures, treatment of pain with strong opioid medication is not superior to milder medication, according to a study published online November 17 in JAMA Network Open.
Deanne E. Jenkin, PhD, from the University of South Wales in Sydney, and colleagues conducted a double-blind, superiority, randomized clinical trial at a single-center, major trauma hospital to compare analgesia with strong and mild opioids. Participants were inpatients who had sustained an acute nonpathological fracture of a long bone or the pelvis, patella, calcaneus, or talus who were treated with surgical fixation. One hundred twenty patients were randomly assigned as follows: 59 to strong opioids (mean oral morphine equivalent of 32.9mg for days 1 to 7) and 61 to mild opioids (mean oral morphine equivalent of 5.5mg for days 1 to 7).
The researchers found that from days 1 to 7 postdischarge, the mean daily Numerical Pain Rating Scale (NRS) mean pain score was 4.04 and 4.54 in the strong and mild opioid groups, respectively (between-group difference, −0.50; 95% CI, −1.11 to 0.12; P =.11).
“These findings suggest that ongoing strong opioid use after discharge from the hospital should not be supported,” the authors write.