HealthDay News — Prostate-specific antigen (PSA) screening is associated with a lower incidence of advanced prostate cancer regardless of statin use, according to a study published online November 24 in JAMA Oncology.

Arla Vettenranta, MD, from Tampere University in Finland, and colleagues assessed whether statin use was associated with the risk for prostate cancer overall, high-risk disease, and prostate cancer mortality in a screening group versus a control group. The analysis included 78,606 men, aged 55 to 67 years at baseline (March 1, 1996, to December 31, 1999), followed through 2015 and with information on statin purchases from 1996 to 2009.

The researchers found that while PSA screening was associated with increased prostate cancer incidence among statin nonusers (screening vs control, 11.2 vs 8.6 per 1000 person-years; rate ratio, 1.31; 95% CI, 1.24 to 1.38), no similar increase in incidence was seen among statin users (6.9 vs 5.9 per 1000 person-years; rate ratio, 1.02; 95% CI, 0.95 to 1.10; P <.001 for interaction). Among statin users, the incidence of low-risk (Gleason score 6) and localized tumors was lower, while the detection of tumors with a Gleason score of 8 to 10 was similar. Regardless of statin use, screening was associated with a lower incidence of metastatic tumors.

“These findings suggest that statin use does not materially compromise benefits of PSA-based screening,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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