A new study found no significant difference in mortality rates when comparing two common blood transfusion methods in patients with severe injuries and major blood loss: a 1:1:1 vs. 1:1:2 ratio of platelets, plasma, and red blood cell units, respectively. The findings are published online in the Journal of the American Medical Association.
Gail Pearson, MD, ScD, Director, Adult and Pediatric Cardiac Research Program, Division of Cardiovascular Sciences at the NHLBI, and colleagues conducted a Phase 3 multi-site, randomized clinical study (n=680) to evaluate the two ratios of blood components (1:1:1 [n=338] vs. 1:1:2 [n=342]) for transfusion in severely injured patients between August 2012 and December 2013.
Researchers found similar mortality rates at 24 hours (12.7% in 1:1:1 group vs. 17.0% in 1:1:2 group; P=0.12) and at 30 days (22.4% vs. 26.1%, respectively; P=0.26) between the two ratios. However, more patients in the 1:1:1 group achieved hemostasis and fewer patients died from exsanguination by 24 hours.
Results from this study show that even with an increased use of plasma and platelets transfused in the 1:1:1 group, there were no other safety differences identified between the two ratios compared.
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