HealthDay News — Sodium-glucose cotransporter 2 inhibitor (SGLT2i) use is associated with a decreased risk for cardiovascular (CV) death or hospitalization for heart failure (HHF) in patients with heart failure and ejection fraction greater than 40%, according to a review and meta-analysis published online Dec. 1 in the European Journal of Preventive Cardiology.

Vasiliki Tsampasian, from University of East Anglia in the United Kingdom, and colleagues conducted a systematic literature review and meta-analysis with a primary end point of CV death and HHF.

Based on 5 studies (9726 patients), the researchers found that the use of SGLT2i was associated with a significant reduction in CV death or HHF (hazard ratio [HR], 0.78; 95% CI, 0.69 to 0.87) and in HHF (HR, 0.71; 95% CI, 0.61 to 0.84) vs placebo. The groups were similar in terms of CV death (HR, 1.01; 95% CI, 0.80 to 1.28) and all-cause mortality (HR, 1.01; 95% CI, 0.89 to 1.14). When limiting the analysis to data for patients with left ventricular ejection fraction greater than 50% (,928 patients), there was a reduction observed in CV death or HHF (HR, 0.77; 95% CI, 0.66 to 0.91) in the SGLT2i group.

“For many years there was not a single medicine that could improve the outcome in patients with the second type of heart failure, those patients with preserved ejection fraction,” a coauthor said in a statement. “This is the first medication that can really improve the outcomes for this patient group, and it will revolutionize the treatment offered to heart failure patients.”

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