HealthDay News — For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published online July 6 in Diabetes Care.
Chin-Li Lu, from the National Cheng Kung University in Tainan, Taiwan, and colleagues examined the effects of severe hypoglycemia on risks of all-cause mortality and CVD incidence in two nested case-control studies conducted within a cohort of 10,411 patients with T1DM in Taiwan. A total of 564 non-survivors and 1,615 controls and 743 CVD cases and 1,439 controls were enrolled between 1997 and 2011. The history of severe hypoglycemia was examined during one year, one to three years, and three to five years before the study outcomes.
The researchers found that the risks of all-cause mortality and CVD were elevated with prior severe hypoglycemic events within one year (adjusted odds ratios, 2.74 and 2.02, respectively). Correlations were also seen for events occurring within one to three and three to five years before death (adjusted odds ratios, 1.94 and 1.68, respectively). Within 5 years there were significant dose-gradient effects of severe hypoglycemia frequency on mortality and CVD.
“Although the CVD incidence may be associated with severe hypoglycemic events occurring in the previous year, the risk of all-cause mortality was associated with severe hypoglycemic events occurring in the preceding five years,” the authors write.