HealthDay News — The risk for advanced colorectal neoplasms (ADNs) 10 or more years after a negative screening colonoscopy is low, according to a study published online January 17 in JAMA Internal Medicine.

Thomas Heisser, from the German Cancer Research Center in Heidelberg, and colleagues assessed the prevalence of ADNs at 10 years or greater after a negative screening colonoscopy among 120,298 repeated screening colonoscopy participants in Germany.

The researchers found that at 10 years, the prevalence of ADNs was 3.6% in women and 5.2% among men, which increased to 4.9 and 6.6%, respectively, among those who had a negative colonoscopy 14 years prior or greater. Among all screening colonoscopies among patients aged 65 years or older (1.25 million) during the same time period, prevalence was 7.1 and 11.6%, respectively. For repeated colonoscopies 10 years or greater after a negative colonoscopy, sex-specific and age-specific prevalence rates of ADNs were consistently at least 40% lower among women than men, lower at younger versus older ages, and much lower than for all screening colonoscopies (standardized prevalence ratios for cancers: 0.22 to 0.38 among women and 0.15 to 0.24 among men; standardized prevalence ratios for ADNs: 0.49 to 0.62 among women and 0.50 to 0.56 among men).

“Extension of the currently recommended 10-year screening intervals may be warranted, especially for female and younger participants without gastrointestinal symptoms,” the authors write.

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