HealthDay News — Patients with multiple myeloma (MM) mount a highly variable antibody response after receipt of a 2-dose mRNA COVID-19 vaccination regimen, according to a study published online June 28 in Cancer Cell.

Oliver Van Oekelen, from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues analyzed SARS-CoV-2 spike-binding immunoglobulin (Ig)G antibody levels in 320 MM patients who received COVID-19 vaccinations (69.1% BNT162b2; 27.2% mRNA-1273; 3.8% unknown) in early 2021.

Two hundred sixty of the participants had SARS-CoV-2 spike-binding IgG antibody levels measured at least 10 days after receipt of the second vaccine dose. The researchers found that 84.2% of the 260 participants mounted measurable SARS-CoV-2 spike-binding IgG antibody levels, with considerable variation in magnitude (median, 149 AU/mL; range, 5 to 7882 AU/mL); 15.8% had values below the level of detection. In a control group of 67 matched health care workers, vaccine-induced antibody responses were more homogenous (median, 300 AU/mL; range, 21 to 3335 AU/mL); none had antibody levels below the level of detection. There were 10 cases of COVID-19 in MM patients after mRNA vaccination (7 after 1 dose; 3 after both doses). Six patients received outpatient treatment and four required subsequent hospitalization.

“Our findings underscore the need for routine serological monitoring of MM patients following COVID-19 vaccination to allow for personalized risk reduction measures in the context of relaxing mask and social distancing mandates for vaccinated individuals,” the authors write.

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Several authors disclosed financial ties to the biopharmaceutical industry; the Icahn School of Medicine at Mount Sinai has filed patent applications relating to SARS-CoV-2 serological assays and Newcastle disease virus-based SARS-CoV-2 vaccines, listing one coauthor as inventor.

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