The FDA has approved Refissa (tretinoin cream [emollient] 0.05%, from Spear Dermatology Products) as an adjunctive agent for use in the mitigation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin in patients who do not achieve such palliation using comprehensive skin care and sun avoidance programs.

Refissa is fragrance-free and is available by prescription as a 40g tube.

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